PET-Computed Tomography and PET-MR Imaging and Their Applications in the Twenty-First Century

Since the discovery of x-ray by Roentgen in 1895, planar radiography has remained a major imaging technique in assessing skeletal abnormalities with reasonable success. However, poor contrast between diseased sites and the background results in low sensitivity of this modality in detecting early disease and monitoring its course over time. The introduction of computed tomography[…]

In Vivo Molecular Imaging of Musculoskeletal Inflammation and Infection

In vivo molecular imaging detects biologic processes at molecular level and provides diagnostic information at an earlier time point during disease onset or repair. It offers definite advantage over anatomic imaging in terms of improved sensitivity and ability to quantify. Radionuclide molecular imaging has been widely used in clinical practice. This article discusses the role of[…]

Metastatic Seeding Attacks Bone Marrow, Not Bone

Conventional modalities, such as bone scintigraphy, are commonly used to assess osseous abnormalities in skeletal metastasis. Fluorine-18 (18F)-sodium fluoride (NaF) PET similarly portrays osteoblastic activity but with improved spatial and contrast resolution and more accurate anatomic localization. However, these modalities rely on indirect evidence for tumor activity. PET imaging with 18F-fluorodeoxyglucose (FDG) and tumor-specific tracers[…]

Applications of PET–Computed Tomography–Magnetic Resonance in the Management of Benign Musculoskeletal Disorders

Although computed tomography (CT) and MR imaging alone have been used extensively to evaluate various musculoskeletal disorders, hybrid imaging modalities of PET-CT and PET–MR imaging were recently developed, combining the advantages of each method: molecular information from PET and anatomical information from CT or MR imaging. Furthermore, different radiotracers can be used in PET to[…]